Deerfield Management Companies

Senior Scientist, Medicinal Chemistry

Job Locations US-MT-Bozeman
Posted Date 2 months ago(3/22/2022 2:58 PM)
# of Openings
Career Area
Research & Development

Overview (Text Only)

Job Title:
Senior Scientist, Medicinal Chemistry
Bozeman, MT
Reports To:
Vice President, Medicinal Chemistry
Position Summary
Vibliome Therapeutics is seeking an experienced, highly skilled, and motivated chemist with exceptional organic synthesis and medicinal chemistry expertise to identify and advance small molecule leads from its novel technology platform.  This position will require the candidate to possess and leverage deep knowledge and capabilities to progress differentiated kinase inhibitors drug discovery programs and advance them towards the clinic.  Using a mix of internal and external resources, the Senior Scientist will be an active member of cross-functional project teams, and be responsible for designing, and delivering high quality lead molecules with an eye toward optimizing lead quality attributes. 
Vibliome is located in Bozeman, MT, ranked number one in the US for economic strength out of 551 micropolitan areas in the US (Policom) in both 2018 and 2019. Home to a world-class research university (top 3% in 2018 by Center for World University Rankings), Bozeman has also been ranked among the Best 20 towns (Outside Magazine), the 7th most educated city in the United States (AdvisorSmith), the Top 25 ski towns in the world (National Geographic), and the top 5 best college towns for skiers (Powder Magazine). Bozeman is located next to Yellowstone National Park in the stunning Rocky Mountains of Southwest Montana. 
For more information on Vibliome, please see our website,

Responsibilities (Text Only)

Roles and Responsibilities of the Position*
- Actively contribute to Vibliome’s project portfolio by designing compounds based on SAR analysis and structure-based drug design (SBDD) concepts
- Evolve hit compounds through lead optimization (LO) utilizing medicinal chemistry concepts and biology data into potential clinical candidates
- Analyze Vibliome’s SAR library and use structure-guided methods and biological insights to design unique lead candidates with differentiated activity profiles suitable for POC animal studies and potential clinical candidates
- Actively support one or more drug discovery projects, working in concert with medicinal chemistry, biology, data science and computational chemistry team leads in the company
- Coordinate with global contract research organizations and collaborators on synthetic chemistry activities, computational chemistry, structural biology, and other key disciplines
- Perform literature reviews, patent searches, design, propose, and execute medicinal chemistry plans, and coordinate chemistry and biology data to support compound progression and patent strategies
- Participate in portfolio and stage-gate reviews, and assist in the preparation and presentation of data packages for lead candidate nomination and compound advancement
- Ensure optimal interaction/communication and provide updates on project status to leadership

Qualifications (Text Only)

- PhD in synthetic organic or medicinal chemistry is preferred
- A minimum of 6 years of experience in the biopharmaceutical industry with a broad and proven track record of innovative accomplishments in medicinal chemistry and key contributions to clinical candidate selection
- Utilizing expert knowledge of modern methods of synthetic and medicinal chemistry to successfully conduct medicinal chemistry on multiple projects
- Solid understanding of cellular/molecular biology, biochemistry, disease pharmacology, mechanisms of drug metabolism and molecular toxicology, pharmaco-kinetic and pharmaco-dynamic sciences, and formulations for the in vivo evaluation of drug candidates is preferred
- Knowledge of and experience with computational chemistry methods including SBDD and biophysical techniques Although this position will primarily work with an external group for synthesis, knowledge of synthetic methods is essential, and occasional synthesis support may be required from time to time
- Strong problem-solving skills for developing creative, innovative solutions, and meeting project objectives are required
- Strong track record of scientific contributions including peer reviewed first-author publications, patent applications, and presentations at major national meetings is preferred
- Interpersonal skills that allow one to be an effective member of an inclusive team are required
Physical Demands / Travel
The physical demands of this position are consistent with working in a laboratory / office environment. Some light lifting and maneuvering may be required.
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
Work Environment
This position’s work environment is based in a laboratory / office environment.
The work environment characteristics described here are representative of those encountered by an employee while performing the essential functions of this job.
*To perform this job successfully, an individual must be able to perform each roles and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.


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