Deerfield Management Companies

Principal Scientist, Medicinal Chemistry

Job Locations US-MT-Bozeman
Posted Date 3 months ago(7/30/2021 1:38 PM)
ID
2021-1543
# of Openings
1
Career Area
Research & Development

Overview (Text Only)

Vibliome Therapeutics is seeking an experienced, highly skilled, and motivated chemist with exceptional organic synthesis and medicinal chemistry expertise to identify and advance small molecule leads from its novel technology platform.  This position will require the candidate to possess and leverage deep knowledge and capabilities to progress differentiated kinase inhibitors drug discovery programs and advance them towards the clinic.  Using a mix of internal and external resources, the Principal Scientist will partner with key stakeholders, represent medicinal chemistry, lead cross-functional project teams, and be co-responsible for building, managing, and delivering high quality clinical molecules. 
 
Vibliome is located in Bozeman, MT, ranked number one in the US for economic strength out of 551 micropolitan areas in the US (Policom) in both 2018 and 2019. Home to a world-class research university (top 3% in 2018 by Center for World University Rankings), Bozeman has also been ranked among the Best 20 towns (Outside Magazine), the 7th most educated city in the United States (AdvisorSmith), the Top 25 ski towns in the world (National Geographic), and the top 5 best college towns for skiers (Powder Magazine). Bozeman is located next to Yellowstone National Park in the stunning Rocky Mountains of Southwest Montana. 
For more information on Vibliome, please see our website, www.vibliome.com.
 

Responsibilities (Text Only)

Roles and Responsibilities of the Position*
- Drive and direct medicinal chemistry functions for one or more drug discovery projects, working in concert with biology and computational chemistry team leads in the company
- Coordinate with global contract research organizations and collaborators on synthetic chemistry activities, pharmacology, computational chemistry, ADME, structural biology, and other key disciplines
- AnalyzeVibliome’s multi-dimension SAR matrix using structure-guided methods and biological insights to identify unique lead candidates with differentiated activity profiles
- Perform literature reviews, design, propose, and execute medicinal chemistry plans, and coordinate chemistry and biology data to support compound progression and patent strategies
- Design of follow-up analogs based on Vibliome’s scaffold technology that consistently move identified projects toward drug-like candidates suitable for POC animal studies and beyond.
- Contribute to the scientific direction and leadership for synthetic and medicinal chemistry activities of internal FTEs
- Participate in portfolio and stage-gate reviews, lead the preparation and presentation of data packages for lead candidate nomination and compound advancement
- Participate in shaping and implementing strategies that support medicinal chemistry growth objectives at Vibliome
- Serve as a scientific expert in medicinal chemistry and provide recommendations regarding new targets and emerging external opportunities
- Ensure optimal interaction/communication and provide updates on project status to leadership
 

Qualifications (Text Only)

Qualifications
- PhD in synthetic organic or medicinal chemistry
- A minimum of 10 years of experience in the biopharmaceutical industry with a broad and proven track record of innovative accomplishments in medicinal chemistry and key contributions to clinical candidate selection
- Demonstrated operational skills for managing discovery programs at the level of a senior chemist/team leader are required
- A proven track record of delivering clinical candidates
- Expert knowledge of modern methods of synthetic and medicinal chemistry with ability to successfully and simultaneously conduct medicinal chemistry on multiple projects
- Solid understanding of cellular/molecular biology, biochemistry, disease pharmacology, mechanisms of drug metabolism and molecular toxicology, pharmaco-kinetic and pharmaco-dynamic sciences, and formulations for the in vivo evaluation of drug candidates is required
- Knowledge of and experience with computational chemistry methods and technologies and biophysical techniques such as X-ray crystallography
- Ability to integrate multiple R&D disciplines into a successful strategic project plan is required
- Strong problem-solving skills for developing creative, innovative solutions, and meeting project objectives are required
- Demonstrated influence, negotiation, and conflict resolution skills, including the ability to succeed within a matrix environment, are required
- Experience in managing project budgets, aligning actions with overall strategy, and supporting business cases for decision-making is preferred
- Strong track record of scientific contributions including peer reviewed first-author publications, patent applications, and presentations at major national meetings is required
 
Physical Demands / Travel
The physical demands of this position are consistent with working in a laboratory/ bench environment. Some light lifting and maneuvering may be required.
The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.
 
Work Environment
This position’s work environment is based in a laboratory/ bench environment.
The work environment characteristics described here are representative of those encountered by an employee while performing the essential functions of this job.
 
*To perform this job successfully, an individual must be able to perform each roles and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
 
Vibliome provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to religion, race, creed, color, sex, sexual orientation, gender identification, alienage or citizenship status, national origin, age, marital status, pregnancy, disability, veteran or military status, predisposing genetic characteristics or any other characteristic protected by applicable federal, state or local law.
 
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